tag:blogger.com,1999:blog-22973357.post5743160192969748494..comments2023-09-27T07:44:19.769-04:00Comments on Sabine Hossenfelder: Backreaction: What I learned todaySabine Hossenfelderhttp://www.blogger.com/profile/06151209308084588985noreply@blogger.comBlogger46125tag:blogger.com,1999:blog-22973357.post-51692876417411397482010-03-26T06:04:01.326-04:002010-03-26T06:04:01.326-04:00Hi everybody,
Regarding proteins folding, the sit...Hi everybody,<br /><br />Regarding proteins folding, the situation is even worse if one considers that many proteins of interest have no pre-determined structure (see <a href="http://en.wikipedia.org/wiki/Intrinsically_unstructured_proteins" rel="nofollow">this</a>). The so-called IUP seems to rapidly shift between different possible stable conformations so to adapt to several molecular targets. Jérôme Chauvethttps://www.blogger.com/profile/02545307794681614263noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-15116372157451420922010-03-19T21:07:10.268-04:002010-03-19T21:07:10.268-04:00My last comment on this subject so as to get back ...My last comment on this subject so as to get back to Bee's post.<br /><br />Just a couple of points to clarify.<br /><br />Thin-Film Solar with High Efficiency<br /><br />The idea:A vehicles surface is never altogether flat in relation to the sun, and as the vehicle moves the sun over head is always changing angles in respect to the vehicle, so, you have to capture the sun "in spots"PlatoHagelhttps://www.blogger.com/profile/00849253658526056393noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-15021601146246597432010-03-19T20:05:11.064-04:002010-03-19T20:05:11.064-04:00In general DNA topology does not influence protein...In general DNA topology does not influence protein folding. There may be some exceptions in bacteria where transcription of DNA into mRNA and translation of mRNA into proteins are closely linked but it's very unlikely in eucariotes where both processes are decoupled and happen at different time and place. <br /><br />As for the folding model it seems like a huge simplification of what Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-27888466342465538732010-03-19T14:55:46.803-04:002010-03-19T14:55:46.803-04:00Lunch break.
hmmm...I don't have that breadth...Lunch break.<br /><br />hmmm...I don't have that breadth of knowledge plato.<br /><br />I think given life's preference for metabolic processes at 310K, that this temperature probably represents some optimum balance between high altitude cloud cover and terrestrial thermal luminosity, that maximizes the entropy increase in the incident solar flux. So anything that can keep the Earth Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-33041482066474985902010-03-19T13:23:26.993-04:002010-03-19T13:23:26.993-04:00Hmm..interesting Aaron.
Bee and Stefan have alway...Hmm..interesting Aaron.<br /><br />Bee and Stefan have always kept an inducible environment too thought production wile keeping science interesting.<br /><br />I mean if ever we to construct a computer based on <a href="http://en.wikipedia.org/wiki/Photosynthetically_active_radiation" rel="nofollow">quantum chlorophyll correlations of the photosynthetic process</a> closely related to activation PlatoHagelhttps://www.blogger.com/profile/00849253658526056393noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-62665174851646412112010-03-19T11:52:42.862-04:002010-03-19T11:52:42.862-04:00Sorry one more comment on the double life of ATP.
...Sorry one more comment on the double life of ATP.<br /><br />Biological systems have a relatively small number of direct chemical reactions available to modulate enzyme function. Basically phosphorylation and methylation. However there are a large number of substrates available to act on: the 5 nucleic acids, and the 23 amino acids.<br /><br />So for example the nucleic acid adenosine, can be Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-24302795870320128512010-03-19T11:34:45.939-04:002010-03-19T11:34:45.939-04:00After my dozen comment rant on entropy change in t...After my dozen comment rant on entropy change in the solar photon flux on Cosmic Variance, I can reasonably hypothesize that, given the purpose of life is to maximize the entropy in the solar photon flux, this amounts to keeping the Earth as warm as possible while minimizing the formation of upper atmospheric clouds.<br /><br />The reason is that the Earth maximally increases the entropy in the Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-1957874968068658532010-03-19T11:22:12.125-04:002010-03-19T11:22:12.125-04:00“You don’t see what you’re seeing until you see it...<i>“You don’t see what you’re seeing until you see it,” Dr. Thurston said, “but when you do see it, it lets you see many other things.<a href="http://www.nytimes.com/2006/08/15/science/15math.html" rel="nofollow">Elusive Proof, Elusive Prover: A New Mathematical Mystery</a></i><br /><br /><br /><a href="http://www.ba.infn.it/~gasperin/f1.gif" rel="nofollow">Pre-big-bang scenario: the general PlatoHagelhttps://www.blogger.com/profile/00849253658526056393noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-13484249617073029392010-03-19T11:05:00.337-04:002010-03-19T11:05:00.337-04:00Well in cosmology there is only this universe, and...Well in cosmology there is only this universe, and it came from where?<br /><br />So one has to look for "the proo" somewhere as to the cosmological state of the universe.<br /><br />I mean that's where <a href="http://www.absoluteastronomy.com/topics/Gabriele_Veneziano" rel="nofollow">Veneziano</a> comes in right?:)PlatoHagelhttps://www.blogger.com/profile/00849253658526056393noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-68713933935737917912010-03-19T10:55:49.997-04:002010-03-19T10:55:49.997-04:00And yet Bee, scientists who seek the production of...And yet Bee, scientists who seek the production of life on Earth (beginning with the simplest amino acids) from given initial conditions of the early Earth a mere half-billion years after formation when it is assumed conditions seem to have been conducive to life-formation (the time itself not being in contention given the fossil record), have run into considerable roadblocks.<br /><br />How can Steven Colyerhttps://www.blogger.com/profile/10435759210177642257noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-72979399631850164562010-03-19T10:54:28.106-04:002010-03-19T10:54:28.106-04:00Well, ask yourself it it's more promising to t...Well, ask yourself it it's more promising to trying to explain the emergence of life on another planet and then try to get it here.Sabine Hossenfelderhttps://www.blogger.com/profile/06151209308084588985noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-5769503121840197632010-03-19T10:52:32.393-04:002010-03-19T10:52:32.393-04:00This comment has been removed by the author.Steven Colyerhttps://www.blogger.com/profile/10435759210177642257noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-341826574207117992010-03-19T10:50:22.792-04:002010-03-19T10:50:22.792-04:00Only cosmologists like to think inside the box Ste...Only cosmologists like to think inside the box Steven:) <br /><br />As if out of some Jack Nicholson phrase, "they can't handle the truth?":)<br /><br />I swear, your going to get "bumped" out of your orbit some day:)<br /><br />Best,PlatoHagelhttps://www.blogger.com/profile/00849253658526056393noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-78518281621984195152010-03-19T10:41:57.336-04:002010-03-19T10:41:57.336-04:00Well, yes, there's plenty of science fiction t...Well, yes, there's plenty of science fiction that plays with the idea (you know, at some point we Earthlings discover our true home etc). While it doesn't seem impossible, it also doesn't seem particularly likely. Best,<br /><br />B.Sabine Hossenfelderhttps://www.blogger.com/profile/06151209308084588985noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-91785689135569727492010-03-19T10:38:59.378-04:002010-03-19T10:38:59.378-04:00Have ye ever heard of Panspermia, the idea that li...Have ye ever heard of <a href="http://en.wikipedia.org/wiki/Panspermia" rel="nofollow">Panspermia</a>, the idea that life's origin is not only endemic to Earth, but that Earth life started somewhere else, perhaps in another now dead solar system (thanks to novae), and I see no reason to not keep extrapolating backwards to another galaxy as well. <br /><br />Our solar system is a young-un, a Steven Colyerhttps://www.blogger.com/profile/10435759210177642257noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-86548479204821062062010-03-19T10:34:22.985-04:002010-03-19T10:34:22.985-04:00This comment has been removed by the author.Steven Colyerhttps://www.blogger.com/profile/10435759210177642257noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-16444440232178332492010-03-19T09:28:15.437-04:002010-03-19T09:28:15.437-04:00One of the first and most enduring facts most stud...<i>One of the first and most enduring facts most students learn in biology class is that all living cells use a small molecule called adenosine triphosphate (ATP) as fuel. <b>That universal energy currency drives the biological reactions</b> that allow cells to function and life to flourish—making ATP a crucial player in the biological world.</i><a href="http://www.scientificamerican.com/PlatoHagelhttps://www.blogger.com/profile/00849253658526056393noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-15026279697631751662010-03-18T23:04:41.683-04:002010-03-18T23:04:41.683-04:00In relation to metabolism there is more or less a ...In relation to metabolism there is more or less a constant amount of ATP in the body. The 50kg/day number can literally be translated by molar relations into the number of Krebs cycles processed in the body in a single day. So the number is a measure of metabolic activity, not actual mass output or input.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-12028617586419542112010-03-18T20:24:53.862-04:002010-03-18T20:24:53.862-04:00There was an article in SciAm about ATP last Decem...There was an <a href="http://www.scientificamerican.com/article.cfm?id=the-double-life-of-atp" rel="nofollow">article in SciAm about ATP</a> last December, which I found quite surprising: ATP has many more functions in the body than just in metabolism. But no idea how this may influence the production rate...<br /><br />Cheers, Stefanstefanhttps://www.blogger.com/profile/09495628046446378453noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-14482255706140980552010-03-18T16:09:12.129-04:002010-03-18T16:09:12.129-04:00Hello Bee,
here is a Wikipedia-Link:
http://en.wik...Hello Bee,<br />here is a Wikipedia-Link:<br />http://en.wikipedia.org/wiki/Chaperone_%28protein%29<br />I knew about chaperons vaguely, but I did not remember <br />exactly. <br />This is a quite sophisticated <br />folding "apparatus", not easily <br />compatible with the ideas You heard of in <br />that seminar. <br />Regards<br />GeorgGeorghttps://www.blogger.com/profile/02538391164351204407noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-40482005936397272912010-03-18T14:55:22.886-04:002010-03-18T14:55:22.886-04:00Its lunch time in Mountain Standard Time.Its lunch time in Mountain Standard Time.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-26482918900728933412010-03-18T14:43:04.794-04:002010-03-18T14:43:04.794-04:00Hi Aaron,
Oh, wow, you beat me to it. I meant to ...Hi Aaron,<br /><br />Oh, wow, you beat me to it. I meant to check the number, but couldn't find the time. I suppose though most of the energy goes into maintaining a constant body temperature, not thinking? Best,<br /><br />B.Sabine Hossenfelderhttps://www.blogger.com/profile/06151209308084588985noreply@blogger.comtag:blogger.com,1999:blog-22973357.post-1665760824043145122010-03-18T14:34:25.880-04:002010-03-18T14:34:25.880-04:00the 50kg/day so ATP processed sounded off so from:...the 50kg/day so ATP processed sounded off so from:<br /><br />http://en.wikipedia.org/wiki/Basal_metabolic_rate<br /><br />and<br /><br />http://en.wikipedia.org/wiki/Adenosine_triphosphate<br /><br />We can estimate the human metabolic consumption at 6000kJ/day using the Katch-McArdle formula, and converting calories to joules.<br /><br />The Gibbs Free energy per mole of ATP of the Krebs CycleAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-1469035758355920102010-03-18T14:11:36.774-04:002010-03-18T14:11:36.774-04:00This comment has been removed by the author.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-22973357.post-29219295177295512632010-03-18T12:44:07.970-04:002010-03-18T12:44:07.970-04:00Yes... I believe the speaker said something like t...Yes... I believe the speaker said something like that. You know, there's research showing the average person can learn 7 new information items per hour. My 7 items were exhausted after the introduction. Today I learned the following: "Your body produces and destroys 50kg of ATP per day, half it's body weight." Okay, so, unless I've exaggerated the chocolate intake lately, Sabine Hossenfelderhttps://www.blogger.com/profile/06151209308084588985noreply@blogger.com